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March 6, 2001
Dr. Paul Connett
Professor of Chemistry
St. Lawrence University, NY 13617
315-229-5853 ggvideo@northnet.org
with assistance from:
Michael Connett
Webmaster
Fluoride Action Network
http://www.fluoridealert.org
50 Reasons to Oppose Fluoridation
(Click here for Printer-Friendly Format of the 50 Reasons)
1) Fluoride is not an essential nutrient. No disease has ever been linked to a fluoride deficiency.
Humans can have perfectly good teeth without fluoride.
2) Fluoridation is not necessary. Most Western European countries are not fluoridated and have
experienced the same decline in dental decay as the US (see data from World Health
Organization on levels of tooth decay in Europe, US, New Zealand, and Australia in
Appendix 1).
3) Fluoridation's role in the decline of tooth decay is in serious doubt. The largest survey ever
conducted in the US (over 39,000 children from 84 communities) by the National Institute of
Dental Research showed little difference in tooth decay among children in fluoridated and
non-fluoridated communities (Hileman, 1989 and Yiamouyiannis, 1990). According to the NIDR's
statisticians, the study found an average difference of only 0.6 DMFS (Decayed Missing and Filled
Surfaces) in the permanent teeth of children aged 5-17 residing in either fluoridated or unfluoridated
areas (Brunelle and Carlos, 1990). This difference is less than one tooth surface! There are 128
tooth surfaces in a child's mouth.
4) Where fluoridation has been discontinued in communities from Canada, the former East
Germany, Cuba and Finland, dental decay has not increased but has actually decreased
(Maupome et al, 2001; Kunzel and Fischer,1997,2000; Kunzel et al, 2000 and Seppa et al,
2000).
5) One of the early trials which helped to launch fluoridation took place in Newburgh, NY, with
Kingston, NY as the control community. After 10 years of this trial (which was methodologically
flawed), it looked as if there was a large decrease in dental caries in the fluoridated community
compared to the non-fluoridated community. However, when children were re-examined in these
two cities in 1995 (50 years after the trial began) there was practically no difference in the dental
decay in the two communities. If anything, the teeth in unfluoridated Kingston were slightly better
(Kumar and Green 1998).
6) Modern research (e.g. Diesendorf, 1986; Colquhoun, 1997, and De Liefde, 1998) shows that
decay rates were coming down before fluoridation was introduced and have continued to decline
even after its benefits would have been maximized. Many other factors influence tooth decay.
Studies in India (Teotia and Teotia, 1994) and Tuczon, Arizona (Steelink, 1992) have shown that
tooth decay actually increases as the fluoride concentration in the water increases.
7) Leading dental researchers (Levine, 1976; Fejerskov, Thylstrup and Larsen, 1981; Carlos,
1983; Featherstone, 1987, 1999, 2000; Margolis and Moreno, 1990; Clark, 1993; Burt, 1994;
Shellis and Duckworth, 1994 and Limeback, 1999, 2000), and the Centers for Disease Control
and Prevention (CDC, 1999) are now acknowledging that the mechanism of fluoride's benefits are
mainly TOPICAL not SYSTEMIC. Thus, you don't have to swallow fluoride to protect teeth. As
the benefits of fluoride (if they exist) are topical, and the risks are systemic, it makes more sense,
for those who want to take the risks, to deliver the fluoride directly to the tooth in the form of
toothpaste. Since swallowing fluoride is unnecessary, there is no reason to force people (against
their will) to drink fluoride in their water suppy. (All the referencs for "topical versus systemic
benefits" are listed as a group in the reference section).
8) The US fluoridation program has massively failed to achieve one of its key objectives, i.e. to
lower dental decay rates while minimizing dental fluorosis (mottled and discolored enamel). The
goal of the early promoters of fluoridation was to limit dental fluorosis (in its mildest form) to 10%
of children (NRC, 1993, pp. 6-7). The percentage of children with dental fluorosis in optimally
fluoridated areas is up to EIGHT TIMES this goal (Williams, 1990; Lalumandier, 1995; Heller,
1997 and Morgan, 1998). The York Review estimates that up to 48% of children in optimally
fluoridated areas have dental fluorosis in all forms and up to 12.5% in the mild to severe forms
(McDonagh, 2000).
9) Dental fluorosis means that a child has been overdosed on fluoride. While the mechanism by
which the enamel is damaged is not definitively known, it appears fluorosis may be a result of either
inhibited enzymes in the growing teeth (Dan Besten 1999), or through fluoride's interference with
the thyroid gland.
10) The level of fluoride put into water (1 ppm) is 100 times higher than normally found in mothers'
milk (0.01 ppm) (Institute of Medicine, 1997). There are no benefits, only risks, for infants
ingesting this heightened level of fluoride at such an early age (this is an age where susceptibility to
environmental toxins is particularly high).
11) Fluoride is a cumulative poison. Only 50% of the fluoride we ingest each day is excreted
through the kidneys, the remainder accumulates in our bones, pineal gland, and other tissues. If the
kidney is damaged, fluoride accumulation will increase.
12) Fluoride is very biologically active even at low concentrations. It interferes with hydrogen
bonding which is central to the structure and function of proteins and nucleic acids. Thus, fluoride
has the potential to disrupt events at the very heart of living things (Emsley, 1981).
13) Fluoride inhibits enzymes in test tubes (Waldbott, 1978), in bacteria in the oral cavity
(Featherstone, 2000), in the growing tooth (DenBesten, 1999), in bone (Krook and Minor, 1998)
and in other tissues (Luke, 1998).
14) Fluoride has been shown to be mutagenic, cause chromosome damage and interfere with the
enzymes involved with DNA repair in a variety of insect, tissue culture and animal studies (DHSS,
1991, Mihashi and Tsutsui, 1996).
15) Fluoride administered to animals at high doses wreaks havoc on the reproductive system - it
renders sperm non-functional and increases the rate of infertility (Chinoy, et al, 1995; Kumar &
Susheela, 1994; Chinoy & Narayana, 1994; Chinoy & Sequeira, 1989). A recent study from the
US found increased rates of infertility among women living in areas with 3 or more ppm fluoride in
the water. According to this latter study, which was published in the Journal of Toxicology and
Environmental Health, "Most regions showed an association of decreasing TFR [Total Fertility
Rate] with increasing fluoride levels" (Freni 1994).
16) Fluoride forms complexes with a large number of metals, which include metals which are
needed in the body (like calcium and magnesium) and metals (like lead and aluminum) which are
toxic to the body. This can cause a variety of problems. For example, fluoride interferes with
enzymes where magnesium is an important co-factor, and it can help facilitate the uptake of
aluminum into tissues where the aluminum wouldn't otherwise go.
17) Rats fed for one year with 1 ppm fluoride in doubly distilled and de-ionized water, using either
sodium fluoride or aluminum fluoride, had morphological changes to their kidneys and brains and
had an increased level of aluminum present in their brain (Varner et al, 1998). Aluminum in the
brain is associated with Alzheimers disease.
18) Fluoride and aluminum fluoride complexes interact with G-proteins and thus have the potential
to interfere with many hormonal and some neurochemical signals (Struneka and Patocka, 1999).
19) Aluminum fluoride was recently nominated by the Environmental Protection Agency and
National Institute of Environmental Health Sciences for testing by the National Toxicology
Program. According to the EPA and NIEHS, aluminum fluoride currently has a "high health
research priority" due to its "known neurotoxicity" (BNA, 2000). If fluoride is added to water
which contains aluminum, than aluminum fluoride complexes will form.
20) Animal experiments show that fluoride exposure alters mental behavior (Mullenix et al, 1995).
Rats dosed prenatally demonstrated hyperactive behavior. Those dosed postnatally demonstrated
hypoactivity (i.e. under activity or "couch potato" syndrome).
21) Studies by Jennifer Luke (1997) showed that fluoride accumulates in the human pineal gland
to very high levels. In her Ph.D thesis Luke has also shown in animal studies that fluoride reduces
melatonin production and leads to an earlier onset of puberty.
22) Three studies from China show a lowering of IQ in children associated with fluoride exposure
(Li et al, 1995; Zhao et al, 1996 and Lu et al, 2000). Another study (Lin et al, 1991) indicates that
even just moderate levels of fluoride exposure (e.g. 0.9 ppm in the water) can exacerbate the
neurological defects of iodine deficiency, which include decreased IQ and retardation. (According
to the CDC, iodine deficiency has nearly quadrupled in the US since the 1970's, with nearly 12%
of the population now iodine deficient.)
23) Earlier in the 20th century, fluoride was prescribed by a number of European doctors to
reduce the activity of the thyroid gland for those suffering from hyperthyroidism (over active
thyroid) (Merck Index, 1960, p. 952; Waldbott, et al., 1978, p. 163). With water fluoridation, we
are forcing people to drink a thyroid-depressing medication which could serve to promote higher
levels of hypothyroidism (underactive thyroid) in the population, and all the subsequent problems
related to this disorder. Such problems include depression, fatigue, weight gain, muscle and joint
pains, increased cholesterol levels, and heart disease.
It bears noting that according to the Department of Health and Human Services (1991) fluoride
exposure in fluoridated communities is estimated to range from 1.58 to 6.6 mg/day, which is a
range that actually overlaps the dose (2.3 - 4.5 mg/day) shown to decrease the functioning of the
human thyroid (Galletti & Joyet, 1958). This is a remarkable fact, and certainly deserves greater
attention considering the rampant and increasing problem of hypothyroidism in the United States.
(In 1999, the second most prescribed drug of the year was Synthroid, which is a hormone
replacement drug used to treat an underactive thyroid).
24) Some of the early symptoms of skeletal fluorosis, a fluoride-induced bone and joint disease
that impacts millions of people in India, China, and Africa , mimic the symptoms of arthritis.
According to a review on fluoridation by the journal of the American Chemical Society, "Because
some of the clinical symptoms mimic arthritis, the first two clinical phases of skeletal fluorosis could
be easily misdiagnosed" (Hileman, 1988). Few if any studies have been done to determine the
extent of this misdiagnosis, and whether the high prevalence of arthritis in America (over 42 million
Americans have it) is related to our growing fluoride exposure, which is highly plausible. The causes
of most forms of arthritis (e.g. osteoarthritis) are unknown.
25) In some studies, when high doses of fluoride were used in trials to treat patients with
osteoporosis in an effort to harden their bones and reduce fracture rates, it actually led to a
HIGHER number of hip fractures (Hedlund and Gallagher, 1989; Riggs et al, 1990).
26) Eighteen studies (four unpublished, including one abstract) since 1990 have examined the
possible relationship of fluoridation and an increase in hip fracture among the elderly. Ten of these
studies found an association, eight did not. One study found a dose-related increase in hip fracture
as the concentration of fluoride rose from 1 ppm to 8 ppm (Li et al, 1999, to be published). Hip
fracture is a very serious issue for the elderly, as a quarter of those who have a hip fracture die
within a year of the operation, while 50 percent never regain an independent existence. (All 18 of
these studies are referenced as a group in the reference section).
27) One animal study (National Toxicology Program, 1990) shows a dose-related increase in
osteosarcoma (bone cancer) in male rats. The initial finding of this study was of "clear evidence of
carcinogenicity" a finding which was soon conspicuously downgraded to "equivocal evidence"
(Marcus, 1990). EPA Professional Headquarters Union has requested that Congress establish an
independent review of this study's results (Hirzy 2000).
28) Two epidemiological studies show a possible association (which some have discounted:
Hoover, 1990 and 1991) between osteosarcoma in young men and living in fluoridated areas
(National Cancer Institute, 1989 and Cohn, 1992). Other studies have not found this association.
29) Fluoridation is unethical because individuals are not being asked for their informed consent
prior to medication. This is standard practice for all medication.
30) While referenda are preferential to imposed policies from central government, it still leaves the
problem of individual rights versus majority rule. Put another way -- does a voter have the right to
require that their neighbor ingest a certain medication (even if it's against that neighbor's will)?
31) Some people appear to be highly sensitive to fluoride as shown by case studies and double
blind studies (Waldbott, 1978 and Moolenburg, 1987). This may relate to fluoride interfering with
their hormone levels including those produced by their thyroid gland. Can we as a society force
these people to drink fluoride?
32) According to the Agency for Toxic Substances and Disease Registry (ATSDR, 1993) some
people are particularly vulnerable to fluoride's toxic effects; these include: the elderly, diabetics and
people with poor kidney function. Again, can we in good conscience force these people to ingest
fluoride on a daily basis?
33) Also vulnerable are those who suffer from malnutrition (e.g. calcium, magnesium, vitamin C,
vitamin D and iodide deficiencies and protein poor diets). Those most likely to suffer from poor
nutrition are the poor, who are precisely the people being targeted by new fluoridation proposals
(Oral Health in America, May 2000). While being at heightened risk, poor families are less able to
afford avoidance measures (e.g. bottled water or removal equipment).
34) Since dental decay is most concentrated in poor communities, we should be spending our
efforts trying to increase the access to dental care for poor families. The real "Oral Health Crisis"
that exists today in the United States, is not a lack of fluoride but poverty and lack of dental
insurance.
35) Fluoridation has been found to be ineffective at preventing one of the most serious oral health
problems facing poor children, namely, baby bottle tooth decay, otherwise known as early
childhood caries (Jones, 2000).
36) Once fluoride is put in the water it is impossible to control the dose each individual receives.
This is because, one, some people (e.g. manual laborers, athletes and diabetics) drink more water
than others, and because, two, we receive fluoride from sources other than the water supply. Other
sources of fluoride include food and beverages processed with fluoridated water; fluoridated dental
products, and pesticide residues on food.
As one doctor has aptly stated, "No physician in his right senses would prescribe for a person he
has never met, whose medical history he does not know, a substance which is intended to create
bodily change, with the advice: 'Take as much as you like, but you will take it for the rest of your
life because some children suffer from tooth decay. ' It is a preposterous notion."
37) Despite the fact that it is recognized that we are ingesting too much fluoride, and despite the
fact that we are exposed to far more fluoride in 2000 than we were in 1945 (when fluoridation
began), the "optimal" fluoridation level is still 1 part per million, the same level deemed optimal in
1945!
38) The early studies conducted in 1945 -1955 in the US, which helped to launch fluoridation,
have been heavily criticized for their poor methodology and poor choice of control communities
(De Stefano, 1954; Sutton 1959, 1960 and 1996). According to Dr. Hubert Arnold, a statisician
from the University of California at Davis, the early fluoridation trials "are especially rich in fallacies,
improper design, invalid use of statistical methods, omissions of contrary data, and just plain
muddleheadedness and hebetude."
39) The US Public Health Service first endorsed fluoridation in 1950, before one single trial had
been completed (McClure, 1970)! It may not be coincidental that in the same year of the US PHS
endorsement, the Sugar Research Foundation, Inc. (supported by 130 corporations) expressed its
aim in dental research as, "To discover effective means of controlling tooth decay by methods other
than restricting carbohydrate (sugar) intake" (Waldbott, 1965, p.131).
40) The fluoridation program has been very poorly monitored. There has never been a
comprehensive analysis of the fluoride levels in the bones of the American people. US Health
authorities have no idea how close we are getting to levels which will cause subtle or even serious
bone and joint damage!
41) According to a letter received by New Jersey Assemblyman John Kelly, the Food and Drug
Administration (FDA) has never approved the fluoride supplements given to children, which are
designed to deliver the same amount of fluoride as fluoridated water.
42) The chemicals used to fluoridate water in the US are not pharmaceutical grade. Instead, they
come from the wet scrubbing systems of the superphosphate fertilizer industry. These chemicals
(90% of which are sodium fluorosilicate and fluorosilicic acid), are classified hazardous wastes
contaminated with toxic metals and trace amounts of radioactive isotopes. Recent testing by the
National Sanitation Foundation suggest that the levels of arsenic in these chemicals are high and of
significant concern.
43) These hazardous wastes have not been tested comprehensively. The chemical usually tested in
animal studies is pharmaceutical grade sodium fluoride, not industrial grade fluorosilicic acid. The
assumption being made is that by the time this waste product has been diluted down, all the
fluorosilicic acid will have been converted into free fluoride ion, and the other toxics and radioactive
isotopes will be so dilute that they will not cause any harm, even with lifetime exposure. These
assumptions have not been examined carefully by scientists, independent of the fluoridation
program.
44) Studies by Masters and Coplan (1999) show an association between the use of fluorosilicic
acid (and its sodium salt) to fluoridate water and an increased uptake of lead into children's blood.
45) Sodium fluoride is an extremely toxic substance -- just 3 to 5 grams, or about one teaspoon, is
enough to kill a human being. Both children (swallowing gels) and adults (accidents involving
malfunctioning of fluoride delivery equipment and filters on dialysis machines) have died from
excess exposure.
46) Some of the earliest opponents of fluoridation were biochemists and at least 14 Nobel Prize
winners are among numerous scientists who have expressed their reservations about the practice of
fluoridation (see appendix 4 for list). Dr. James Sumner, who won the Nobel Prize for his work on
enzyme chemistry, had this to say about fluoridation: "We ought to go slowly. Everybody knows
fluorine and fluoride are very poisonous substancesWe use them in enzyme chemistry to poison
enzymes, those vital agents in the body. That is the reason things are poisoned; because the
enzymes are poisoned and that is why animals and plants die" (Connett, 2000).
Last year's (2000) recipient of the Noble Prize for Medicine and Physiology, was Dr. Arvid
Carlsson of Sweden. Dr. Carlsson was one of the leading opponents of fluoridation in Sweden. He
was part of the panel that recommended that the Swedish government reject the practice, which
they did in 1971. In her book "The Fluoride Question: Panacea or Poison" Anne-lise Gotzsche
quotes Carlsson as follows: "It is not worthwhile to conceal the fact that it is a question of applying
a pharmacologically active substance to an entire population" (p.69).
47) The Union representing the scientists at the US EPA headquarters in DC is on record as
opposing water fluoridation (Hirzy, 1999) and rejects the US EPA's approval of the use of
hazardous industrial waste products to fluoridate the public water supply.
48) Many scientists, doctors and dentists who have spoken out publicly on this issue have been
subjected to censorship and intimidation (Martin 1991). Tactics like this would not be necessary if
those promoting fluoridation were on secure scientific ground.
49) Promoters of fluoridation refuse to recognize that there is any scientific debate on this issue,
despite the concerns listed above and objective reviews of the controversy (Hileman, 1988). Dr.
Michael Easley, one of the most vocal proponents, goes so far as to say that there is no legitimate
debate, whatsoever, concerning fluoridation. According to Easley, who works closely with the
CDC and ADA, "Debates give the illusion that a scientific controversy exists when no credible
people support the fluorophobics' view." Easley adds that
"a most flagrant abuse of the public trust occasionally occurs when a physician
or a dentist, for whatever personal reason, uses their professional standing in
the community to argue against fluoridation, a clear violation of professional
ethics, the principles of science and community standards of practice" (Easley,
1999).
Comments like these led the associate technical director for Consumers Union, Dr. Edward Groth,
to conclude that "the political profluoridation stance has evolved into a dogmatic, authoritarian,
essentially antiscientific posture, one that discourages open debate of scientific issues" (Martin,
1991).
50) When it comes to controversies surrounding toxic chemicals, invested interests traditionally do
their very best to discount animal studies and quibble with epidemiological findings. In the past,
political pressures have led government agencies to drag their feet on regulating asbestos, benzene,
DDT, PCBs, tetraethyl lead, tobacco and dioxins. With fluoridation we have had a fifty year delay.
Unfortunately, because government officials have put so much of their credibility on the line
defending fluoridation, and because of the huge liabilities waiting in the wings if they admit that
fluoridation has caused an increase in hip fracture, arthritis, bone cancer, brain disorders or thyroid
problems, it will be very difficult for them to speak honestly and openly about the issue. But they
must, not only to protect millions of people from unnecessary harm, but to protect the notion that,
at its core, public health policy must be based on sound science not political pressure. They have a
tool with which to do this: it's called the Precautionary Principle. Simply put, this says: if in doubt
leave it out. This is what most European countries have done and their children's teeth have not
suffered, while their public's trust has been strengthened.
It is like a question from a Kafka play. Just how much doubt is needed on just one of the health
concerns identified above, to override a benefit, which when quantified in the largest survey ever
conducted in the US, amounts to less than one tooth surface (out of 128) in a child's mouth?
For those who would call for further studies, we say fine. Take the fluoride out of the water first
and then conduct all the
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